Vascular endothelial function in salt sensitive and non-salt sensitive subjects

VernacularTitle:血压盐敏感者早期血管内皮功能改变研究
Author: Jian-Jun MU ¹ ; Tao ZHANG ; Yuan FANG ; Jie REN ; Wei-Min LIU ; Zhi-Quan LIU
Author Information

1. 西安交通大学医学院附属第一医院
Keywords: Salt; Blood pressure; Endothelium,vascular
From: Chinese Journal of Cardiology 2011;39(1):61-64
CountryChina
Language:Chinese
Abstract: Objective Salt-sensitivity is associated with more severe target organ injury and higher mortality in patients with essential hypertension. We compared the vascular endothelial function between saltsensitive subjects(SS)and non-salt-sensitive subjects(NSS)with normal or mildly increased blood pressure. Methods Ninety-nine subjects(aged 16-60 years)with normal blood pressure or mild hypertension(degree 1)were enrolled. The test program included 3 days baseline investigation, 1 week lowsalt loading phase and 1 week high-salt loading phase. Endothelial function was assessed by measuring the flow mediated dilatation(FMD)of the brachial artery using high resolution ultrasound. Results There was 17. 2% SS. Plasma NOx level[(61.2 ± 13. 3)μmol/L vs(82. 5 ± 14. 6)μmol/L, P ＜ 0. 05]and FMD [(10.2±2.5)%vs(14.5 ± 1.6)%, P ＜0.05]were significantly lower in SS subjects than in NSS subjects. Conclusion Vascular endothelial dysfunction was evidenced in SS subjects with normal blood pressure or in the early stage of hypertension.