Induction and regulation of cellulase expression in filamentous fungi: a review.

Fei ZHANG; Fengwu BAI; Xinqing ZHAO

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Induction and regulation of cellulase expression in filamentous fungi: a review.

Author: Fei ZHANG ¹ ; Fengwu BAI ¹ ; Xinqing ZHAO ²
Author Information

1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China.
2. State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Publication Type:Journal Article
Keywords: Trichoderma reesei; cellulase; gene expression and regulation; transcription factor
From: Chinese Journal of Biotechnology 2016;32(11):1481-1495
CountryChina
Language:Chinese
Abstract: Production of bioenergy and bio-based chemicals by using fermentable sugars released from low-cost renewable lignocellulosic biomass has received great attention. Efficient cellulolytic enzymes are crucial for lignocellulose bioconversion, but high cellulase production cost is limiting the bioconversion efficiency of cellulosic biomass and industrial applications of lignocellulose biorefinery. Studies on induction and regulation of cellulase in filamentous fungi will help to further develop superior fungal strains for efficient cellulase production and reduce cellulase production cost. With the advances in high-throughput sequencing and gene manipulation technology using fungal strains, an in-depth understanding of cellulase induction and regulation mechanisms of enzyme expression has been achieved. We reviewed recent progresses in the induction and regulation of cellulase expression in several model filamentous fungi, emphasizing sugar transporters, transcription factors and chromatin remodeling. Future prospects in application of artificial zinc finger proteins for cellulase induction and regulation in filamentous fungi were discussed.