Status and advances of long-acting factor Ⅷ.

Author: Dan LU ¹ ; Fanyi ZENG ¹
Author Information

1. Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200040, China.
Publication Type:Journal Article
Keywords: hemophilia A; interaction between FⅧ and vWF; long-acting clotting factor Ⅷ; recombinant protein; von Willebrand factor
From: Chinese Journal of Biotechnology 2018;34(1):34-43
CountryChina
Language:Chinese
Abstract: Current treatment for hemophilia A is based on replacement therapy that is the most effective method by using recombinant clotting factor FⅧ (rFⅧ). Although the safety and effectiveness of replacement therapy has been proved by clinical practice for the last decades, FⅧ products are temporally limited because of a short half-life and requiring prophylactic injections frequently for most patients, usually three times per week or every other day. Frequent intravenous injection not only brings physical pain to the patient, but also produces FⅧ antibodies that seriously affect the treatment effect. In this paper, we review the present status, research progress and main problems of the long-acting recombinant factor Ⅷ.