Expression of integrin-linked kinase in oral squamous cell cancinoma and its significance
10.3760/cma.j.issn.1002-0098.2010.10.014
- VernacularTitle:口腔鳞状细胞癌中整联蛋白连接激酶的表达及意义
- Author:
Zhu-Ling GUO
1
;
Yan GAO
Author Information
1. 北京大学口腔医学院口腔医院
- Keywords:
Mouth neoplasms;
Carcinoma,squamous cell;
Immunohistochemistry;
Integrinlinked kinase
- From:
Chinese Journal of Stomatology
2010;45(10):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression patterns of integrin-linked kinase (ILK) in oral squamous cell carcinoma(OSCC). MethodsThe expression of ILK in 170 OSCC cases was examined by immunohistochemistry and periodic acid-schiff histochemistry. ResultsILK immunoreactivity occurred in cancer cells and(or) stroma encircling the malignant tissue. Along with the deteriorated histopathologic grade of oral cancer, there was stepwise aberration exhibiting from ILK-negative, to ILK-positive in epithelia, to ILK-positive in both epithelia and stroma, and to ILK-positive in stroma.Through nonparameter test, in both lymphatic invasion [ILK-positive in stroma in well-differentiated、 moderatelydifferentiated and poorly-differentiated is 2% (1/50), 18% (6/33) and 64% (18/28), respectively] and non-lymphatic invasion group [ILK-positive in stroma in well-differentiated、 moderately-differentiated and poorly-differentiated is 16% (4/25), 9/18 and 10/16, respectively), the expression patterns of ILK exhibited significant correlations with histopathology (F = 17. 742, P ＜0. 001 ,F =4. 394, P =0. 017). ILK expression between lymphatic metastasis and non-lymphatic metastasis group was significantly different (x2 = 14. 418, P =0. 002). ConclusionsILK inclines to express in stroma during the OSCC progress.
