Diagnosis and treatment of wild-type gastrointestinal stromal tumors.
- Author:
Hui CAO
1
;
Ming WANG
Author Information
1. Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. caohuishcn@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Gastrointestinal Neoplasms;
pathology;
therapy;
Gastrointestinal Stromal Tumors;
therapy;
Genotype;
Humans;
Mutation;
Proto-Oncogene Proteins c-kit;
Receptor, Platelet-Derived Growth Factor alpha
- From:
Chinese Journal of Gastrointestinal Surgery
2014;17(4):312-316
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal stromal tumors(GIST) are the most common mesenchymal tumors of the gastrointestinal tract, and are mostly characterized by c-kit or PDGFRA gain-of-function mutation. About 10%-15% of GIST do not harbor any mutations in the c-kit and PDGFRA genes and are defined as wild-type GIST. There are significant differences in molecular mechanism and clinical characteristics between wild-type GIST and mutant GIST. Wild-type GIST should be considered as a family of diseases due to their extreme heterogeneity. Clinician should pay close attention to the diagnosis and treatment of wild-type GIST.
