Chinese herbal drugs for erectile dysfunction through NO-cGMP-PDE5 signaling pathway.
- Author:
Hui LIAO
1
;
Rajfer JACOB
Author Information
1. Department of Pharmacy, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China. liao_hui@21cn.com
- Publication Type:Journal Article
- MeSH:
Animals;
Cyclic GMP;
metabolism;
Cyclic Nucleotide Phosphodiesterases, Type 5;
metabolism;
Drugs, Chinese Herbal;
therapeutic use;
Erectile Dysfunction;
drug therapy;
metabolism;
Flavonoids;
therapeutic use;
Male;
Nitric Oxide;
metabolism;
Phytotherapy;
Rabbits;
Rats;
Signal Transduction
- From:
National Journal of Andrology
2012;18(3):260-265
- CountryChina
- Language:Chinese
-
Abstract:
Great progress has been made in the basic researches on erectile dysfunction (ED) ever since the recognition of the close association of micromolecular nitric oxide (NO) with penile smooth muscle relaxation in 1990. NO-cGMP-PDE5 signaling pathway plays an important role in regulating the relaxation of corpus cavernosum smooth muscle, and its relevant studies have contributed greatly to the clinical treatment of ED. Chinese herbal drugs have long been used in the treatment of ED, and the action mechanisms of some of them clarified through the NO-cGMP-PDE5 signaling pathway. This article presents an overview on the recent advances in the studies of ED treatment with Chinese herbal drugs.
