Identification of viable myocardium delayed enhancement magnetic resonance imaging and 99Tcm-sestamibi or 18F-fluorodeoxyglucose single photon emission computed tomography.
- Author:
Shi-Hua ZHAO
1
,
2
;
Chao-Wu YAN
;
Min-Fu YANG
;
Min-Jie LU
;
Shi-Liang JIANG
;
Shi-Guo LI
;
Yan ZHANG
;
Qiong LIU
;
Yu-Qing LIU
;
Zuo-Xiang HE
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Cell Survival; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; methods; Male; Middle Aged; Myocardial Infarction; diagnostic imaging; Myocytes, Cardiac; diagnostic imaging; metabolism; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; methods
- From: Chinese Journal of Cardiology 2006;34(12):1072-1076
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of this study was to investigate the feasibility and accuracy of delayed enhancement magnetic resonance imaging (DE-MRI) for the assessment of myocardial viability in patients with myocardial infarction in comparison with (99)Tc(m)-sestamibi (MIBI) single photon emission computed tomography (SPECT) and (18)F-fluorodeoxyglucose (FDG) SPECT. Scar was defined as regionally increased MRI signal intensity 15 minutes after injection of 0.2 mmol/kg gadolinium-diethylenetriamine pentaacetic acid or reduced perfusion and glucose metabolism defined by SPECT.
METHODSA total of 34 patients with myocardial infarction (29 males, 58.0 +/- 9.8 years) were imaged with MRI and SPECT.
RESULTSA total of 578 segments were analyzed. DE-MRI and SPECT identified 431 and 336 viable segments respectively and SPECT also identified 30 ischemic segments. Necrotic segments identified by DE-MRI and SPECT were 147 and 212 respectively. Sensitivity and specificity of DE-MRI in identifying segments with matched flow/metabolism defects (scar tissues) was 61.3% and 95.4%, respectively. Quantitatively assessed relative MRI infarct area correlated well with SPECT infarct size. The value of Kappa was 0.51.
CONCLUSIONDE-MRI provides a good tool for differentiating viable myocardium from scar tissues and the detection accuracy is comparable between DE-MRI and SPECT.
