The expression of hypoxia inducible factor 1-alpha in lung cancer and its correlation with P53 and VEGF.
- Author:
Huilan ZHANG
1
;
Zhenxiang ZHANG
;
Yongjian XU
;
Lihua XING
;
Jianbo LIU
;
Jun LI
;
Qing TAN
Author Information
1. Department of Respiratory Diseases, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
metabolism;
pathology;
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit;
biosynthesis;
genetics;
Lung Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Mutation;
Tumor Suppressor Protein p53;
biosynthesis;
genetics;
Vascular Endothelial Growth Factor A;
biosynthesis;
genetics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(2):124-127
- CountryChina
- Language:English
-
Abstract:
To investigate the expression of hypoxia inducible factor 1-alpha (HIF-1alpha) and its correlation with P53 and vascular endothelial growth factor (VEGF), immunohistochemical technique was employed to detect the protein expressions of HIF-1alpha, P53 and VEGF in specimens from 57 patients with lung cancer. The results indicated that the total positive proportion of HIF-1alpha expression was 63% and the HIF-1alpha expression was more frequent in bronchiole-alveolar carcinoma (86%) than in other lung cancer. There was a strong association of HIF-1alpha with VEGF and P53 protein expressions. It is concluded that HIF-1alpha overexpression is a common event in lung cancer, which may be related to the up-regulation of the angiogenic factor VEGF and oncogene mutant P53 protein.
