Preparation of tanshinone microemulsion and its absorption in rat intestine in situ.
- Author:
Hong-lei LI
1
;
Zhong-yi ZHANG
;
Lei-lei MA
;
Xiao-yu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diterpenes, Abietane; Emulsions; Intestinal Absorption; Intestine, Small; metabolism; Male; Particle Size; Phenanthrenes; administration & dosage; isolation & purification; pharmacokinetics; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; chemistry; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2007;32(11):1024-1027
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare tanshinone microemulsion (Tan-ME) and investigate its properities and the absorption character in rat intestine in situ.
METHODThe microemulsions were prepared and characterized using Zetapals Zeta potential/particle size analysis and atomic force microscope. A HPLC method for determination of tanshinone IIA in the intestinal flux was established. RESUILT: The Tan-ME was fine droplet with an average droplet size of (32.25 +/- 6.59) nm. The results of Tan-ME absorption in small intestinal indicated that Tan-ME could improve the absorption of tanshinone IIA in rat small intestine, but the absorption coefficient of Tan-ME, Ka was influenced by the ratio of water-phase in Tan-ME.
CONCLUSIONTan-ME could improve the absorption of tanshinone IIA in rat small intestine. Thus bioavailability of tanshinone was improved.
