Diagnostic value of microtubule-associated protein-2 in small cell lung carcinoma: an analysis of 240 biopsy cases.
- VernacularTitle:微管相关蛋白-2在240例活检肺小细胞癌中的诊断价值
- Author:
Dong-mei ZHOU
1
;
Yu SUN
;
Xiang-hong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; metabolism; Biopsy; CD56 Antigen; metabolism; Chromogranin A; metabolism; Female; Humans; Immunohistochemistry; Lung Neoplasms; diagnosis; metabolism; pathology; Male; Microtubule-Associated Proteins; metabolism; Middle Aged; Nuclear Proteins; metabolism; Sensitivity and Specificity; Small Cell Lung Carcinoma; diagnosis; metabolism; pathology; Synaptophysin; metabolism; Thyroid Nuclear Factor 1; Transcription Factors; metabolism
- From: Chinese Journal of Pathology 2013;42(5):321-324
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the diagnostic value of microtubule-associated protein-2 (MAP-2) in biopsy of small cell lung carcinoma (SCLC).
METHODSImmunohistochemical technique was applied to detect the expression of synaptophysin (Syn), chromogranin A (CgA), CD56, MAP-2 and TTF-1 in 240 cases of SCLC from 2008 to 2011 in this hospital.
RESULTSThe positive rate of MAP-2 expression in SCLC was 95.8% (230/240), which was much higher than that of Syn (57.1%, 137/240), CgA (38.8%, 93/240) and CD56 (89.2%, 214/240). The sensitivity and accuracy of MAP-2 (99.1%, 95.4%) expression were also higher than those of Syn (58.3%, 42.5%), CgA (39.9%, 42.5%) and CD56 (91.5%, 87.9%).
CONCLUSIONSMAP-2 is a new neuroendocrine marker with higher sensitivity and accuracy, and thus recommended to be added to the immunohistochemical panel for the diagnosis of SCLC.
