Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub-chronic co-administration of chlorpyrifos and cypermethrin in male Wister rats.
- Author:
Idris Sherifat BANKE
1
;
Ambali Suleiman FOLORUNSHO
2
;
Bisalla MOHAMMED
3
;
Suleiman Mohammed MUSA
4
;
Onukak CHARLES
4
;
Ayo Joseph OLUSEGUN
4
Author Information
- Publication Type:Journal Article
- Keywords: Brain malondialdehyde; Chlorpyrifos; Cognition; Cypermethrin; Melatonin
- From:Asian Pacific Journal of Tropical Biomedicine 2014;4(4):318-323
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats.
METHODSFifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) respectively. Group III was administered with melatonin at 0.5 mg/kg only. Group IV was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)], and Group V was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)] 30 min after melatonin (0.5 mg/kg). The regimens were administered by gavage once daily for 12 weeks. Thereafter, cognitive performances were determined and the brain was evaluated for malonaldehyde concentration.
RESULTSCPF and CYP induced cognitive deficits and increased brain malonaldehyde concentration, which were all ameliorated by melatonin.
CONCLUSIONCognitive deficits elicited by CPF and CYP was mitigated by melatonin due to its antioxidant property.
