Research and application of hepatotoxicity evaluation technique of traditional Chinese medicine.
- Author:
Jie SONG
1
;
Rong-Ling ZHONG
1
;
Zhi XIA
1
;
Hao WU
1
;
Qing-Xiang ZHONG
1
;
Zhen-Hai ZHANG
1
;
Ying-Jie WEI
1
;
Zi-Qi SHI
1
;
Liang FENG
1
;
Xiao-Bin JIA
1
Author Information
- Publication Type:Journal Article
- Keywords: dose-effect-toxicity; epimedium; hepatotoxicity of traditional Chinese medicine; model of disease/syndrome; network toxicology
- From: China Journal of Chinese Materia Medica 2017;42(1):41-48
- CountryChina
- Language:Chinese
- Abstract: The safety of traditional Chinese medicine (TCM) has received the widespread attention in recent years. Hepatotoxicity of TCM is one of the key problems of the safety of TCM. This article summarized research progress and application prospect in the mechanism of TCM hepatotoxicity, biomarkers, toxic omics database, prevention of hepatotoxicity of the liver cell lines, subcellular fraction, three-dimensional cultivation models, the model animals, aiming to provide theoretical basis for TCM toxicity evaluation and technical guidelines, thus promoting the development of TCM toxicity studies. Hope for Chinese medicine liver toxicity evaluation method provides the theoretical foundation and technical guidelines, promote the development and improvement of TCM liver toxicity research system.
