Recent Trends in the Eradication Rates of Second-Line Quadruple 14 Therapy for Helicobacter Pylori and the Clinical Factors that Potentially Affect the Treatment Outcome.
- Author:
Eun Ju CHO
1
;
Dong Ho LEE
;
Jae Young CHUN
;
Jong Kyung CHOI
;
Sung Wook HWANG
;
Sang Hyub LEE
;
Young Soo PARK
;
Jin Hyeok HWANG
;
Jin Wook KIM
;
Sook Hyang JUNG
;
Nayoung KIM
;
Hyun Chae JUNG
;
In Sung SONG
Author Information
1. Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Eradication rate;
Quadruple therapy
- MeSH:
Appointments and Schedules;
Bismuth;
Breath Tests;
Gastritis;
Helicobacter;
Helicobacter pylori;
Humans;
Metronidazole;
Peptic Ulcer;
Tetracycline;
Treatment Outcome
- From:Korean Journal of Gastrointestinal Endoscopy
2009;38(1):14-19
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The present study aimed to evaluate the efficacy of second-line quadruple therapy for treating patients with Helicobacter Pylori, and these patients were treated at our hospitals for September, 2003 through April, 2008 in Seongnam, Korea. METHODS: One hundred and thirty-three patients who failed to respond to the initial PPI-based triple therapy received quadruple therapy, whcih consisted of PPI, bismuth, tetracycline and metronidazole. The patients were divided into two groups. One group was treated for 7 days and the other group was treated for 14 days. Four to six weeks after completing the schedule, a 13C-urea breath test was performed to detect the presence of H. pylori. RESULTS: The overall intention-to-treat and per-protocol (PP) eradication rates were 75.2% and 81.1%, respectively. The PP eradication rates for the years 2003~2004, 2005, 2006 and 2007~2008 were 76.5%, 82.5%, 91.3% and 75%, respectively. There was no significant difference of the eradication rates according to gender, age and the duration of treatment. Yet the eradication rate of the chronic gastritis group (66.7%) was significantly lower than that of the peptic ulcer group (84.7%) (p=0.030). CONCLUSIONS: There was no definite downward trend for the eradication rates of second-line quadruple therapy during the 6 year study period. However, the eradication rate in the recent 2 years guaranteed only a 75% cure rate and the quadruple therapy was less effective for the patients with chronic gastritis. Therefore, a novel, more potent novel second-line regimen may be needed for the eradication of H. pylori.
