A Case of Recalcitrant Pyoderma Gangrenosum Treated by Infliximab.
- Author:
Hong Dae JUNG
1
;
Seong Geun CHI
;
Byung Soo KIM
;
Weon Ju LEE
;
Seok Jong LEE
;
Do Won KIM
Author Information
1. Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea. dockbs@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Infliximab;
Pyoderma gangrenosum
- MeSH:
Antibodies, Monoclonal;
Colchicine;
Dapsone;
Female;
Humans;
Immunosuppressive Agents;
Leg;
Middle Aged;
Neutrophils;
Pyoderma;
Pyoderma Gangrenosum;
Skin Diseases;
Steroids;
Tumor Necrosis Factor-alpha;
Ulcer;
Infliximab
- From:Korean Journal of Dermatology
2009;47(3):343-346
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pyoderma gangrenosum is an uncommon, neutrophilic, ulcerating, chronic dermatosis with obscure etiology. Many therapeutic modalities have been used in the past, but they have not always provided favorable outcomes. Recently, tumor necrosis factor-alpha inhibitors have been gaining attention in the treatment of recalcitrant pyoderma gangrenosum. A 57-year-old woman presented with painful, recurrent erythematous nodules and ulcers on both legs. She had been treated with systemic steroids, immunosuppressants, dapsone, and colchicine, and she experienced improvement with systemic steroids only. After using infliximab (5 mg/kg), she experienced dramatic improvement in her lesions. Thus, we report a recalcitrant case of pyoderma gangrenosum that was successfully treated with infliximab.
