Clinical Significance of Antikeratin Antibody in Korean Patients with Rheumatoid Arthritis.
- Author:
Eun Bong LEE
1
;
Yun Jong LEE
;
Ki Chun SHIN
;
Young Joo CHOI
;
Han Joo BAEK
;
Seong Wook KANG
;
Yeong Wook SONG
Author Information
1. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. ysong@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Antikeratin antibody;
Rheumatoid arthritis;
Rheuamtoid factor;
Morning stiffness
- MeSH:
Animals;
Antibodies;
Antibodies, Antinuclear;
Arthritis, Rheumatoid*;
Epithelium;
Esophagus;
Fluorescent Antibody Technique, Indirect;
Hand Strength;
Humans;
Joints;
Lupus Erythematosus, Systemic;
Prevalence;
Rats;
Rheumatoid Factor;
Sensitivity and Specificity
- From:The Journal of the Korean Rheumatism Association
1999;6(4):310-318
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Antikeratin antibody is an autoantibody to the cornified epithelium of rat esophagus and known to be a specific marker in Caucasian patients with rheumatoid arthritis. This study was performed to evaluate the prevalence and clinical correlation of the antibody in Korean patients with rheumatoid arthritis. METHOD: We measured antikeratin antibodies by indirect immunofluorescence method and evaluated functional class, anatomical stage, grip strength, Ritchie articular index, tender joint count, swollen joint count, rheumatoid factor and antinuclear antibody in 88 patients with rheumatoid arthritis, 20 patients with systemic lupus erythematosus and 43 healthy controls. RESULTS: The sevsitivity and specificity of the antikeratin antibody test was 48% and 98% respectively in Korean patients with rheumatoid arthritis. Intensity of antikeratin antibody was correlated with duration of morning stiffness(r=0.22, p=0.01) and rheumatoid factor titer(r=0.23, p=0.04). Antikeratin antibody was positive in 8(31%) out of 26 patients without rheumatoid factor. CONCLUSION: Antikeratin antibody is a specific marker in Korean patients with rheumatoid arthritis and correlated with duration of morning stiffness and rheumatoid factor titer.
