Glucosamine Sulfate and Chondroitin Sulfate for the Treatment of Osteoarthritis.
10.4078/jkra.2008.15.3.197
- Author:
Young Ho LEE
1
;
Jong Dae JI
;
Gwan Gyu SONG
Author Information
1. Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. lyhcgh@korea.ac.kr
- Publication Type:Review ; Meta-Analysis
- Keywords:
Glucosamine;
Chondroitin;
Osteoarthritis
- From:The Journal of the Korean Rheumatism Association
2008;15(3):197-203
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Osteoarthritis (OA) is the most common form of arthritis often associated with morbidity, disability, functional impairment and impaired quality of life. A new perspective in OA management is to delay disease progression by modifying joint structure. Glucosamine sulfate (GS) and chondroitin sulfate (CS) have attracted a lot of interest as a specific drug for OA. Glucosamine is a constituent of glcosaminoglycans in cartilage matrix and synovial fluid and is involved in cartilage formation. Chondroitin sulfate (CS) belongs to the glycosaminoglycan group and is a major component of the articular cartilage. The meta-analyses have shown that GS (but not glucosamine hydrochloride) and CS have small-to-moderate symptomatic efficacy in OA. With respect to the structure-modifying effect, there is some evidence that GS and CS may interfere with structural progression of OA.
