Alteration of Brain-Derived Neurotrophic Factor Levels in Panic Disorder.
10.4306/jknpa.2015.54.4.482
- Author:
Soo Ah LEE
1
;
Nam In KANG
;
Jeung Hoon LEE
;
Yong Ku KIM
;
Cao Hong ZI
;
Moo Suk LEE
;
Jong Il PARK
;
Tae Won PARK
;
Jong Chul YANG
Author Information
1. Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea. yangjc@jbnu.ac.kr
- Publication Type:Original Article
- Keywords:
BDNF;
Neurotrophin;
Panic disorder
- MeSH:
Anxiety;
Brain-Derived Neurotrophic Factor*;
Cognition;
Enzyme-Linked Immunosorbent Assay;
Humans;
Neurogenesis;
Panic Disorder*;
Panic*;
Plasma;
Plastics
- From:Journal of Korean Neuropsychiatric Association
2015;54(4):482-488
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in neurogenesis and synaptic plasticity, has been implicated in the pathophysiology of several neuropsychiatric disorders. However, there have been no consistent findings regarding BDNF levels in panic disorder. In this study, we investigated plasma BDNF levels in panic disorder, and evaluated whether there is an association between plasma BDNF levels and severity of symptoms of panic disorder. METHODS: Plasma BDNF levels were measured in 110 panic disorder patients and 110 normal control subjects using the enzyme-linked immunosorbent assay. The severity of symptoms of panic disorder was determined using the Panic Disorder Severity Scale, Acute Panic Inventory, Agoraphobic Cognition Questionnaire, and Hamilton Anxiety Rating Scale. RESULTS: The mean plasma BDNF levels of patients with panic disorder were significantly lower compared with those of control subjects (192.50 pg/mL vs. 693.75 pg/mL). No significant association was observed between plasma BDNF levels and the severity of symptoms of panic disorder. CONCLUSION: These results suggest that BDNF may play a potential role in the pathophysiology of panic disorder.
