The Effects of 0.5% Apraclonidine on Optic Nerve Head and Peripapillary Retinal Microcirculation.
- Author:
Tae Woo KIM
1
;
Dong Myung KIM
;
Won Ryang WEE
;
Jin Hak LEE
;
Bong Leen CHANG
Author Information
1. Department of Ophthalmology, Seoul National University Hospital.
- Publication Type:Original Article
- Keywords:
Apraclonidine;
Microcirculation;
Scanning laser Doppler flowmetry
- MeSH:
Hemodynamics;
Intraocular Pressure;
Laser-Doppler Flowmetry;
Microcirculation*;
Optic Disk*;
Optic Nerve*;
Retina;
Retinaldehyde*
- From:Journal of the Korean Ophthalmological Society
1997;38(12):2172-2176
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To examine the effects of 0.5% apraclonidine on optic nerve head (ONH) and peripapillary microcirculation, scanning laser Doppler flowmetry was performed before and 1 honr, and 3 hours after administration of 0.5% apraclonidine in 10 healthy subjects. In each occasion, 3 scans were obtained. Hemodynamic parmeters (volume, flow, and velocity0 were found at 8 locations, 4 in the neural rim and 4in the peripapillary retina. The intraocular pressure was reduced significantly in apraclonidine-treated eyes by 15.4% (p<.05) at 1 hour and 30.1% (p<.01)at 3 hours after administration. There was no significant change in the volume, flow or velocity of ONH and peripapillary retinal blood flow after apraclonidine administration. In conclusion, single-dose of topical apraclonidine 0.5% in healthy subjects does not have adverse effects on the microcirculation in ONH and peripapillary retina.
