G-CSF Mobilized Peripheral Blood Human Hematopoietic CD34+ Stem Cells Therapy for Acute Stroke: Preliminary Results.
- Author:
Jung Yong AHN
1
;
In Bo HAN
;
Dong Ku KIM
Author Information
1. Department of Neurosurgery, Cerebrovascular Center, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Acute stroke;
Cell transplantation;
Hematopoietic stem cells;
CD34;
Vascular endothelial growth factor
- MeSH:
Cause of Death;
Cell Transplantation;
Central Nervous System;
Cerebral Arteries;
Cerebral Hemorrhage;
Granulocyte Colony-Stimulating Factor*;
Hematopoietic Stem Cells;
Humans*;
Korea;
Middle Cerebral Artery;
Recovery of Function;
Rupture;
Stem Cells*;
Stroke*;
Transplants;
Vascular Endothelial Growth Factor A
- From:Korean Journal of Cerebrovascular Surgery
2006;8(4):235-240
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Acute stroke caused by cerebral artery occlusion or rupture is the most important vascular central nervous system disorder in Korea and remains a leading cause of death and disability despite significant clinical benefits after current treatment modalities. Therefore, it is crucial to develop new alternative therapeutic strategies. The most encouraging approach is directed towards cell transplantation into damaged regions. We discuss the ideal candidate for cell transplantation in current status and preliminary results of peripheral blood stem cells transplantation for acute stroke. METHODS: Five patients with acute stroke (three patients with deep intracerebral hemorrhage and two patients with middle cerebral artery occlusion) underwent peripheral blood stem cells transplantation stereotactically. RESULTS: Cell transplantation of three patients did not improve motor function recovery, as evidenced by NIHSS. However, interestingly, cell transplantation significantly increased CSF levels of vascular endothelial growth factor (VEGF). CONCLUSION: Cell transplantation did correlate positively with elevated growth factor levels in CSF, but not with improved motor function.
