Prognostic Value of Sex-Hormone Receptor Expression in Non-Muscle-Invasive Bladder Cancer.
10.3349/ymj.2014.55.5.1214
- Author:
Jong Kil NAM
1
;
Sung Woo PARK
;
Sang Don LEE
;
Moon Kee CHUNG
Author Information
1. Department of Urology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. toughkil76@naver.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Androgen receptor;
estrogen receptor beta;
urinary bladder neoplasms
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Transitional Cell/*metabolism/pathology;
Disease Progression;
Disease-Free Survival;
Female;
Humans;
Male;
Middle Aged;
Multivariate Analysis;
Neoplasm Invasiveness;
Prognosis;
Receptors, Androgen/*metabolism;
Receptors, Estrogen/*metabolism;
Retrospective Studies;
Risk Factors;
Tumor Markers, Biological/*metabolism;
Urinary Bladder Neoplasms/*metabolism/pathology;
Young Adult
- From:Yonsei Medical Journal
2014;55(5):1214-1221
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated sex-hormone receptor expression as predicting factor of recurrence and progression in patients with non-muscle invasive bladder cancer. MATERIALS AND METHODS: We retrospectively evaluated tumor specimens from patients treated for transitional cell carcinoma of the bladder at our institution between January 2006 and January 2011. Performing immunohistochemistry using a monoclonal androgen receptor antibody and monoclonal estrogen receptor-beta antibody on paraffin-embedded tissue sections, we assessed the relationship of immunohistochemistry results and prognostic factors such as recurrence and progression. RESULTS: A total of 169 patients with bladder cancer were evaluated in this study. Sixty-threepatients had expressed androgen receptors and 52 patients had estrogen receptor beta. On univariable analysis, androgen receptor expression was significant lower in recurrence rates (p=0.001), and estrogen receptor beta expression was significant higher in progression rates (p=0.004). On multivariable analysis, significant association was found between androgen receptor expression and lower recurrence rates (hazard ratio=0.500; 95% confidence interval, 0.294 to 0.852; p=0.011), but estrogen receptor beta expression was not significantly associated with progression rates. CONCLUSION: We concluded that the possibility of recurrence was low when the androgen receptor was expressed in the bladder cancer specimen and it could be the predicting factor of the stage, number of tumors, carcinoma in situ lesion and recurrence.
