Comparison of palonosetron with ondansetron in preventing postoperative nausea and vomiting after thyroidectomy during a 48-hour period.
- Author:
Yu Yil KIM
1
;
Dong Un SONG
;
Ki Hyun LEE
;
Il Jung LEE
;
Jae Wook SONG
;
Jin Hun LIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju, Korea. zion_yuyil@yahoo.co.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Ondansetron;
Palonosetron;
Postoperative nausea and vomiting (PONV);
Thyroidectomy
- MeSH:
Anesthesia, General;
Antiemetics;
Female;
Humans;
Incidence;
Isoquinolines;
Nausea;
Ondansetron;
Postoperative Nausea and Vomiting;
Quinuclidines;
Thyroidectomy;
Vomiting
- From:Anesthesia and Pain Medicine
2012;7(4):312-316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Postoperative nausea and vomiting (PONV) are common complications after general anesthesia. This study compared the effects of palonosetron and ondansetron in preventing PONV in patients undergoing thyroidectomy. METHODS: 100 non-smoking female subjects were randomly assigned to a palonosetron group (n = 50) or an ondansetron group (n = 50). The patients of each group received 0.075 mg of palonosetron or 8 mg of ondansetron through intravenous bolus injection before induction of general anesthesia. The incidence of nausea and vomiting were monitored at 2 h, 24 h and 48 h after operation. RESULTS: The incidence of PONV during 48 h after operation had no significant differences between the groups. However, the incidence of nausea was lower in the palonosetron group than in the ondansetron group (34% vs. 56%, P = 0.027). No differences were observed in incidences of vomiting, use of antiemetics and adverse events between the groups. CONCLUSIONS: Palonosetron was more effective than ondansetron in preventing nausea for patients undergoing thyroidectomy. However, the effect of palonosetron or ondansetron in preventing PONV was similar.
