Five-year Follow-up of Clinical and Laboratory Data of Early Liver Cirrhosis Patients Confirmed by Liver Biopsy.
- Author:
Dong Uk KIM
1
;
Geun Tae PARK
;
Dong Hee KOH
;
Hyun Seok CHO
;
Young Hoon KIM
;
Sung Gon SHIM
;
Jin Bae KIM
;
Sung Hee LEE
;
Ho Soon CHOI
;
Joon Soo HAHM
;
Min Ho LEE
Author Information
1. Research Institute of Digestive Disease, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. minho@hanyang.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Liver cirrhosis;
Shunt index;
p-value
- MeSH:
Adult;
*Biopsy, Needle;
English Abstract;
Female;
Follow-Up Studies;
Human;
Liver/*pathology;
Liver Circulation;
Liver Cirrhosis/complications/*pathology/physiopathology;
Male;
Middle Aged;
Prognosis
- From:The Korean Journal of Hepatology
2002;8(3):256-263
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: It is important to evaluate the general status of the liver including the structural and inflammatory aspects, as well as the functional aspects, in order to determine a patient's treatment modality and prognosis. METHODS: 55 Child-Pugh class A liver cirrhosis patients confirmed by liver biopsy have been categorized into 4 groups based on the shunt index and p-value(Y= 3.3431 - 0.8160 ALT/AST ratio-0.0343 X prothrombin time+2.6963 X shunt index, p = e(y)/(e(y)+1)), which was obtained by Thallium- 201 scan ; group I - shunt index less than 0.3 and p-value less than 0.7; group II - shunt index less than 0.3 and p-value more than 0.7; group III - shunt index more than 0.3 and p-value less than 0.7; and group IV - shunt index more than 0.3 and p-value more than 0.7. Statistical analyses used were ANOVA, paired t-test, and Chi-square test. RESULTS: 1. The laboratory data after a 5-year follow-up also showed a significant difference between four groups. 2. In group IV, the Child-Pugh class after 5 years worsened, and complications of liver cirrhosis such as esophageal varix, ascites, and hepatic encephalopathy occurred more frequently. 3. In group II, the laboratory data after a 5-year follow-up indicated some improvement. CONCLUSION: It can be seen that even early in patients with initially the same cirrhosis, the course of the illness can progress to a variety of different situations. The measurement of shunt index and the p-value of cirrhosis will be more helpful in the follow-up evaluation and predicting its prognostic index in liver cirrhosis patients.
