Novalis Radiosurgery of Primary Central Nervous System Lymphoma in Elderly Patients: Preliminary Results.
- Author:
Seong Rok HAN
1
;
Gi Taek YEE
;
Chan Young CHOI
;
Moon Jun SOHN
;
Dong Joon LEE
;
Choong Jin WHANG
Author Information
1. Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. hsrkmj@ilsanpaik.ac.kr
- Publication Type:Original Article
- Keywords:
Lymphoma;
Elderly;
Radiotherapy;
Radiosurgery;
Novalis
- MeSH:
Aged*;
Central Nervous System*;
Drug Therapy;
Female;
Follow-Up Studies;
Humans;
Karnofsky Performance Status;
Lymphoma*;
Lymphoma, Non-Hodgkin;
Male;
Radiosurgery*;
Radiotherapy;
Retrospective Studies
- From:Journal of Korean Neurosurgical Society
2006;39(6):409-412
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Primary central nervous system lymphoma(PCNSL) is a non-Hodgkin's lymphoma arising in the central nervous system. Combined chemotherapy and radiation therapy is the standard treatment for PCNSL. However, treatment induced neurotoxicity is a major problem especially in elderly patients. METHODS: From May 2001 to April 2004, elderly five patients with PCNSL confirmed via pathological examination were underwent Novalis radiosurgery in authors' institution, who were investigated retrospectively. Of these patients, 2 were male and 3 were female, with a mean age 68 years old (range 65~73). The number of lesions was 1 in 2 patients, 2 in 2, and 3 in 1. The mean follow up period was 12.6 months (range 8~16). RESULTS: Clinical symptoms and signs in all patients markedly improved within 1 weeks after Novalis radiosurgery. The Karnofsky performance status score was also improved from a pre-radiosurgery average of 68 to a post-radiosurgery one of 82. All of treated lesions showed a partial or complete regression of the original mass. There have been no complication following Novalis radiosurgery. CONCLUSION: The preliminary results of our experience indicate that radiosurgery with Novalis provides a safe and effective therapeutic alternative treatment of PCNSL in elderly patients.
