Tumor Necrosis Factor-alpha in Midtrimester Amniotic Fluid is Associated with Pregnancy Outcome?.
- Author:
Hyung Min CHOI
1
;
Jae Sung CHO
;
Kyung Soo KIM
;
Young Ho YANG
;
Yong Won PARK
;
Jae Wook KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
TNF-alpha;
Amniotic fluid;
Midtrimester;
Pregnancy outcome
- MeSH:
Amniotic Fluid*;
Case-Control Studies;
Female;
Fetal Growth Retardation;
Humans;
Necrosis;
Obstetric Labor, Premature;
Pregnancy;
Pregnancy Outcome*;
Pregnancy Trimester, Second*;
Pregnancy*;
Tumor Necrosis Factor-alpha*
- From:Korean Journal of Obstetrics and Gynecology
1997;40(2):281-285
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Our purpose is to investigate if tumor necrosis factor-alpha(TNF-alpha) levels in midtrimester correlate with pregnancies complicated by preterm labor, preeclamsia, and intrauterine growth retardation(IUGR). STUDY DESIGN: A case control study design was used to compare midtrimester amniotic fluid TNF-alpha levels from women with normal pregnancy outcome(n=54) and pregnancies complicated by preterm labor(n=10), preeclampsia(n=8), and IUGR(n=4). RESULT: TNF-alpha levels in midtrimester amniotic fluid in women with normal pregnancy ourcome were 8.8+/-4.0pg/ml. Also, TNF-alpha levels in women with preterm labor, preeclamsia, and IUGR were 9.7+/-6.0pg/ml, 6.0+/-4.1pg/ml, 7.5+/-2.6pg/ml respectively. CONCLUSION: TNF-alpha levels in midtrimester amniotic fluid do not correlate with pregnancies complicated by preterm labor, preeclamsia, and IUGR different from the third trimester(p=0.06).
