Protective Effect of Preoperative Intraocular Pressure Reduction on Corneal Endothelium in Cataract Surgery.
10.3341/jkos.2015.56.4.521
- Author:
Yong Sun AHN
1
;
Yang Kyung CHO
Author Information
1. Department of Ophthalmology and Visual Science, The Catholic University of Korea College of Medicine, Seoul, Korea. yangkyeung@hanmail.net
- Publication Type:Original Article
- Keywords:
Corneal endothelium;
Mannitol;
Microphthalmos;
Phacoemulsification;
Shallow anterior chamber
- MeSH:
Anterior Chamber;
Cataract*;
Cell Count;
Cornea;
Endothelial Cells;
Endothelium, Corneal*;
Humans;
Injections, Intravenous;
Intraocular Pressure*;
Mannitol;
Microphthalmos;
Phacoemulsification;
Postoperative Period;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2015;56(4):521-531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate whether intraocular pressure reduction by intravenous injection of mannitol before phacoemulsification-cataract surgery can have a protective effect on corneal endothelium. METHODS: Patients undergoing sequential bilateral cataract surgery were divided into 2 groups, 36 eyes with anterior chamber depth (ACD) < 2.50 mm (group A) and 44 eyes with ACD > or = 2.50 mm (group B). In each group, preoperative intravenous injection of mannitol was performed in 1 randomly selected eye of the patient. The specular microscopic examination including cell density (ECD), coefficient of variation (CV), hexagonality (HA) of corneal endothelium, and corneal thickness was performed on postoperative 1 day, 2 weeks, and 5 weeks. In each group, the parameters were compared between the eyes with mannitolization and the contralateral eyes without mannitolization. RESULTS: In group A, eyes with preoperative mannitolization showed significantly higher ECD at postoperative 1 day and 5 weeks and showed a significantly thinner cornea at postoperative 1 day than those without mannitolization (all p < 0.05). However, in group B, there was no significant difference of ECD, CV, HA, and corneal thickness between the eyes with and without mannitolization. CONCLUSIONS: Preoperative intraocular pressure reduction by mannitolization before phacoemulsification can protect the corneal endothelial cells and recover the early postoperative period visual acuity in eyes with shallow anterior chamber.
