Antibiotic Resistance for Common Hospital Acquired-pneumonia Pathogens in the Intensive Care Unit of Newly Opened Hospital.
10.4046/trd.2002.52.3.207
- Author:
Jae Hyung LEE
1
;
Sung Joon SHIN
;
Young Chan KIM
;
Seung Il OH
;
Mi Ok KIM
;
Eun Joo PARK
;
Jang Won SOHN
;
Seok Chul YANG
;
Ho Joo YOON
;
Dong Ho SHIN
;
Sung Soo PARK
Author Information
1. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. LEEJH1126@lycos.co.kr
- Publication Type:Original Article
- Keywords:
Antiboitic resistance;
Intensive care unit;
Newly opened hospital
- MeSH:
Academic Medical Centers;
Acinetobacter;
Amikacin;
Anti-Bacterial Agents;
Bacteria;
Ciprofloxacin;
Colon;
Disease Outbreaks;
Drug Resistance, Microbial*;
Gentamicins;
Imipenem;
Intensive Care Units*;
Critical Care*;
Methicillin;
Pseudomonas aeruginosa;
Staphylococcus aureus;
Tobramycin
- From:Tuberculosis and Respiratory Diseases
2002;52(3):207-218
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Intensive care units (ICUs) are generally considered epicenters of antibiotic resistance and the principal sources of multi-resistant bacteria outbreaks. The antibiotic resistance in newly opened intens ive care unit that has no microbial colonization on and around the devices was investigated. METHODS: The authors analyzed the antibiotic resistance patterns for common hospital acquired-pneumonia pathogens in the ICUs(Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter spp.) at the newly opened ICU of Hanyang University Medical Center, Kuri Hospital during 6 years(1995-2000). RESULTS: 1) Regarding Staphylococcus aureus, the resistance rate to methicillin was 15% at 1995, 21% at 1996, 20% at 1997, 23% at 1998, 22% at 1999, 55% at 2000. 2) Regarding Pseudomonas aeruginosa, the resistance rate to 3rd cephalosporin was 50% at 1995, 50% at 1996, 78% at 1997, 40% at 1998, 77% at 1999, 39% at 2000. Imipenam was 0% at 1995, 27% at 1996, 65% at 1997, 12% at 1998, 16% at 1999, 12% at 2000. Ciprofloxacin was 0% at 1996, 56% at 1997, 36% at 1998, 57% at 1999, 58% at 2000. Tobramycin was 7% at 1995, 10% at 1996, 67% at 1997, 36% at 1998, 65% at 1999, 12% at 2000. Gentamycin was 14% at 1995, 36% at 1996, 67% at 1997, 36% at 1998, 65% at 1999, 12% at 2000. Amikacin was 14% at 1995, 30% at 1996, 61% at 1997, 16% at 1998, 39% at 1999, 18% at 2000. 3) Regarding Acinetobacter spp., the resistance rate to 3rd cephalosporin was 92% at 1996, 89% at 1997, 88% at 1998, 84% at 1999, 77% at 2000. Imipenem was 50% at 1996, 48% at 1997, 45% at 1998, 49% at 1999, 50% at 2000. Ciprofloxacin was 0% at 1996, 48% at 1997, 33% at 1998, 27% at 1999, 71% at 2000. Tobramycin was 67% at 1995, 100% at 1996, 93% at 1997, 95% at 1998, 89% at 1999, 77% at 2000. Gentamycin was 67% at 1995, 100% at 1996, 89% at 1997, 95% at 1998, 87% at 1999, 83% at 2000. Amikacin was 33% at 1995, 83% at 1996, 82% at 1997, 88% at 1998, 75% at 1999, 69% at 2000. CONCLUSIONS: The S.aureus resistance to methicillin, the Pseudomonas aeruginosa resistance to ciprofloxacin, and the A cinetobacter spp. resistance to ciprofloxacin have rapidly increased during 6 years. There is a need to pay special attention when using the the antibiotics for the above pathogens. This data may be useful in antibiotic therapy in newly opened intensive care units.
