Effects of Preemptive Gabapentin on Postoperative Pain after Mastectomy.
10.4097/kjae.2004.47.4.527
- Author:
Soon Im KIM
1
;
Dae Yong PARK
;
Si Young OK
;
Sun Chong KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital, Seoul, Korea. soonnim@hosp.sch.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
gabapentin;
postoperative pain
- MeSH:
Analgesia;
Analgesia, Patient-Controlled;
Double-Blind Method;
Fentanyl;
gamma-Aminobutyric Acid;
Humans;
Mastectomy*;
Pain, Postoperative*;
Premedication
- From:Korean Journal of Anesthesiology
2004;47(4):527-531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of the present study was to investigate the effect of preemptive gabapentin on postoperative pain and opioid consumption in patients undergoing mastectomy. METHODS: In a randomized, double-blind study, 41 patients received a single dose of oral gabapentin 900 mg with routine premedicantion (GABA group, n = 21) or only routine premedication without gabapentin (control group, n = 20) 1 h before surgery. Patients received intravenous patient-controlled analgesia using fentanyl for postoperative analgesia. VAS scores for pain at rest and during movement, sedation scores, side effects, and fentanyl consumptions were assessed at 6 and 24 h after surgery. RESULTS: No significant differences were found between the two groups in terms of pain scores, side effects, or fentanyl consumptions for 24 h postoperatively. However, patients in the GABA group were more sedated at 6 h postoperatively than patients in the control group (P < 0.05). CONCLUSIONS: The preemptive administration of oral gabapentin at 900 mg did not reduce postoperative pain or fentanyl consumption after mastectomy during the 24 h period following surgery.
