Changing Patterns of Congenital Anomalies over Ten Years in a Single Neonatal Intensive Care Unit.
10.14734/kjp.2013.24.1.11
- Author:
Sung Hoon CHUNG
1
;
Hee Young KIM
;
Ji Hee KIM
;
Yong Sung CHOI
;
Byong Sop LEE
;
Ki Soo KIM
;
Ellen Ai Rhan KIM
Author Information
1. Division of Neonatology, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan, College of Medicine, Seoul, Korea. arkim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Congenital anomalies;
Single Neonatal Intensive Care Unit;
Incidence;
Mortality
- MeSH:
Birth Weight;
Cleft Lip;
Congenital Abnormalities;
Epidemiologic Studies;
Gestational Age;
Heart Septal Defects, Atrial;
Hernia, Diaphragmatic;
Humans;
Hydrocephalus;
Hydronephrosis;
Hypoplastic Left Heart Syndrome;
Incidence;
Infant, Newborn;
Intensive Care, Neonatal;
Kidney;
Kidney Diseases;
Male;
Mothers;
Nurseries;
Palate;
Polydactyly;
Retrospective Studies;
Trisomy
- From:Korean Journal of Perinatology
2013;24(1):11-19
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate incidence, changing patterns, and mortality associated with congenital anomalies experienced in a single neonatal intensive care unit (NICU). METHODS: Retrospective chart review of 29,026 neonates admitted to NICU and nursery of Asan Medical Center from January 2001 to December 2010 was done. The congenital anomalies were classified according to 76 anomalies in 8 systems registered by Korean Ministry of Health and Welfare in 2009. RESULTS: A total of 3,122 neonates had at least 1 anomaly. Mean gestational age and birth weight were 38(+2)+/-2.3 weeks and 2,030+/-541 g respectively. The proportion of male is 61%. The incidence of congenital anomalies and the proportion of mothers older than 35 years increased from 8.3% to 23.0% and 6.4% to 16.4% in 2001 compared to 2010 respectively. The percentage of neonates who have multiple anomalies was almost equal from 24.0% in 2001 to 23.7% in 2010. The most common anomalies, by system, included atrial septal defect, hydronephrosis, anorectal atresia/stenosis, cystic adenomatoid malformation, cleft lip and/or palate, CATCH 22 syndrome, polydactyly, and hydrocephalus. The overall mortality at 2 years old decreased from 11.1% to 8.0% in 2001 and 2010. Most common etiologies resulting in highest mortality, by system, were hypoplastic left heart syndrome, renal agenesis, congenital diaphragmatic hernia, pulmonary hypoplasia, 18 trisomy, and anancephaly. CONCLUSION: Our data have shown that the incidence of congenital anomaly included in this study is increasing. A detailed epidemiologic study based on larger population is required in order to investigate preventive measures.
