Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy.
- Author:
Won Ho HAHN
1
;
Jin Soon SUH
;
Byoung Soo CHO
Author Information
1. Department of Pediatrics, School of Medicine, East West Kidney Diseases Research Institute Kyung Hee University, Seoul, Korea. bscho@dreamwiz.com
- Publication Type:Original Article
- Keywords:
CCL-2;
MCP-1;
CCL-5;
RANTES;
Chemokine;
Polymorphism;
IgA nephropathy;
Childhood
- MeSH:
Atrophy;
Chemokine CCL5;
Fibrosis;
Foot;
Glomerulonephritis, IGA;
Haplotypes;
Humans;
Immunoglobulin A;
Linkage Disequilibrium;
Podocytes;
Polymorphism, Single Nucleotide;
Proteinuria
- From:Journal of the Korean Society of Pediatric Nephrology
2010;14(1):51-61
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Previous studies have suggested that Chemokine (C-C motif) ligand-2 (CCL-2; also known as MCP-1) and CCL-5 (also known as RANTES) are possibly associated with the pathogenesis of various inflammatory and non-inflammatory renal diseases. The present study was conducted to investigate association of polymorphisms of CCL-2 and CCL-5 genes with childhood IgA nephropathy (IgAN). METHODS: The authors analyzed six single nucleotide polymorphisms (SNPs) of CCL-2 and CCL-5 in 196 pediatric IgAN patients and in 285 healthy controls. We compared variations in SNPs between two several sets of IgAN subgroups, allocated by presence of proteinuria (>4 mg/m2/hour), podocyte foot process effacement, and pathologically advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis. RESULTS: Genotypic data of IgAN patients and controls showed no significant SNP frequency difference in both of of CCL-2 and CCL-5. Even though two linkage disequilibrium blocks were formed, there was no significance in the haplotype analysis. In the patient subgroup analysis, no SNP of CCL-2 and CCL-5 was found to be associated with the presence of proteinuria, podocyte foot process effacement, and pathologically advanced disease markers. CONCLUSION: Our data indicate that no association exists between CCL-2 and CCL-5 SNPs and childhood IgAN susceptibility, and presence of proteinuria, podocyte foot process effacement, and pathologic progression of IgAN.
