A Case of Microscopic Polyangiitis Combined with Limited Systemic Sclerosis.
- Author:
Won Ki LEE
1
;
Yong Beom PARK
;
Hyeon Joo JEONG
;
Soo Kon LEE
Author Information
1. Department of Internal Medicine, Myongji Hospital, Kwandong University College of Medicine, Gyunggi-do, Korea.
- Publication Type:Case Report
- Keywords:
Systemic sclerosis;
Microscopic polyangiitis
- MeSH:
Arm;
Biopsy;
Creatinine;
Cyclophosphamide;
Female;
Filtration;
Fingers;
Glomerulonephritis;
Hematuria;
Humans;
Microscopic Polyangiitis*;
Middle Aged;
Prednisolone;
Proteinuria;
Pulmonary Fibrosis;
Scleroderma, Systemic*;
Skin;
Sural Nerve;
Vasculitis
- From:The Journal of the Korean Rheumatism Association
2003;10(3):310-314
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of microscopic polyangiitis in a 52-year-old woman combined with systemic sclerosis. She was diagnosed as having limited systemic sclerosis based on symmetric skin thickening of fingers and distal arms, loss of substance from the finger pad, and bibasilar pulmonary fibrosis. Laboratory investigations showed positive antitopoisomerase I antibody. Subsequent evaluation revealed proteinuria and hematuria. Her serum creatinine concentration was elevated with detoriorated glomerular filtration. Serum antimyeloperoxidase antibody was strongly positive. A sural nerve biopsy revealed axonopathy due to early manifestations of vasculitis. Percutaneous renal biopsy showed focal necrotizing glomerulonephritis. Her renal function recovered with immunosuppressive therapy with high dose prednisolone and oral cyclophosphamide.
