Prevention and Therapeutic Strategies for Brain Injury in Extreme Prematurity.
10.7599/hmr.2009.29.4.370
- Author:
Hyun Kyung PARK
1
Author Information
1. Department of Pediatrics, School of Medicine, Hanyang University, Seoul, Korea. neopark@hanyang.ac.kr
- Publication Type:Review
- Keywords:
Extreme prematurity;
Brain injury;
Therapeutic strategies
- MeSH:
Birth Weight;
Brain;
Brain Injuries;
Cerebral Palsy;
Hemorrhage;
Humans;
Infant;
Infant, Extremely Premature;
Infant, Newborn;
Intensive Care, Neonatal;
Leukomalacia, Periventricular;
Pregnancy
- From:Hanyang Medical Reviews
2009;29(4):370-378
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
As the evolution of neonatal intensive care has resulted in dramatic improvements in the survival of extremely preterm infants, there is major concern about the increasing rates of neurodisability among those at the limits of viability. Among the infants with parenchymal brain injury such as intraventricular hemorrhage grades III-IV, ventriculomegaly and cystic periventricular leukomalacia, more than 1 out of 3 have one of the cerebral palsy syndrome. However, research examining neuroprotection for brain injury in extremely preterm infants is limited. This review was focused on brain injury and recent strategies for neuroprotection addressing both white matter injury and gray matter dysfunction in infants born <26 weeks' gestation and/or with birth weight less than 750 g.
