Associations of IGF-I, IGFBP-3 on early Catch-up Growth in Small for Gestational Age Infants.
- Author:
Joon Won KANG
1
;
Hye Young HAN
;
Ji Joung LEE
;
Jin Ho CHOI
;
Keon Su LEE
;
Mea young CHANG
Author Information
1. Department of Pediatrics, Graduate School of Medicine, Chungnam National University, Daejeon, Korea. mychang@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Small for gestational age;
IGF-I;
IGFBP-3;
Catch-up growth
- MeSH:
Birth Weight;
Body Weight;
Carrier Proteins;
Female;
Fetal Growth Retardation;
Gestational Age;
Humans;
Infant;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor I;
Male;
Parturition;
Prospective Studies
- From:Korean Journal of Perinatology
2010;21(1):40-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was aimed to analyze the effect of Insulin-like growth factor (IGF)-I and Insulin-like growth factor binding protein (IGFBP)-3 on early catch-up growth in small for gestational age (SGA) infants. METHODS: We prospectively studied in 18 SGA infants who were admitted at Chungnam National University Hospital from January 2004 to January 2006. We divided them into two groups of intrauterine growth retardation; symmetric and asymmetric type. Maternal and neonatal characteristics and the value of IGF-1 and IGFBP-3 at birth were compared between the two groups. After 12 months later, we checked their body weight and height to evaluate catch-up growth. RESULTS: Among 18 SGA infants, 5 were male and 13 were female. Average gestational age at birth was 38.4+/-1.1 weeks. Average birth weight was 2,359+/-154 g. Nine babies showed symmetric intrauterine growth retardation. Thirteen babies achieved catch-up growth at 12 month of age. There was no correlation between the characteristics of SGA and catch-up growth. However, the IGF-I and IGFBP-3 values were significantly higher in babies who showed catch-up growth. CONCLUSION: We were able to predict catch-up growth at early infancy by evaluating serum IGF-I and IGFBP-3 values at birth in SGA infants.
