The Importance of Global Studies of the Genetics of Type 2 Diabetes.

Author: Mark I MCCARTHY ¹
Author Information

1. Oxford Centre for Diabetes, Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, University of Oxford; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK. mark.mccarthy@drl.ox.ac.uk
Publication Type:Review
Keywords: Diabetes mellitus, type 2; Fine-mapping; Genetics; Genome-wide association; Multiethnic; Resequencing; Transethnic
MeSH: Diabetes Mellitus, Type 2; Ethnic Groups; Genome; Humans; Molecular Biology; Phenotype
From:Diabetes & Metabolism Journal 2011;35(2):91-100
CountryRepublic of Korea
Language:English
Abstract: Genome wide association analyses have revealed large numbers of common variants influencing predisposition to type 2 diabetes and related phenotypes. These studies have predominantly featured European populations, but are now being extended to samples from a wider range of ethnic groups. The transethnic analysis of association data is already providing insights into the genetic, molecular and biological causes of diabetes, and the relevance of such studies will increase as human discovery genetics increasingly moves towards sequencing-based approaches and a focus on low frequency and rare variants.