The Glycated Albumin to Glycated Hemoglobin Ratio Might Not Be Associated with Carotid Atherosclerosis in Patients with Type 1 Diabetes.
10.4093/dmj.2014.38.6.456
- Author:
Wonjin KIM
1
;
Kwang Joon KIM
;
Byung Wan LEE
;
Eun Seok KANG
;
Bong Soo CHA
;
Hyun Chul LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. bwanlee@yuhs.ac
- Publication Type:Original Article
- Keywords:
Diabetes mellitus, type 1;
Carotid intima-media thickness;
Glycated albumin to glycated hemoglobin ratio;
Glycosylated serum albumin
- MeSH:
Atherosclerosis;
Body Mass Index;
Carotid Artery Diseases*;
Carotid Intima-Media Thickness;
Creatinine;
Cross-Sectional Studies;
Diabetes Mellitus, Type 1;
Diabetes Mellitus, Type 2;
Female;
Hemoglobin A, Glycosylated*;
Humans;
Insulin;
Male;
Waist Circumference
- From:Diabetes & Metabolism Journal
2014;38(6):456-463
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The ratio of glycated albumin to glycated hemoglobin (GA/A1c) is known to be elevated in subjects with type 2 diabetes mellitus (T2DM) who had decreased insulin secretion. Additionally, the carotid intima media thickness (IMT) is greater in T2DM patients with higher GA/A1c ratios. We investigated whether increased GA/A1c ratio and IMT are also associated in type 1 diabetes mellitus (T1DM), which is characterized by lack of insulin secretory capacity. METHODS: In this cross-sectional study, we recruited 81 T1DM patients (33 men, 48 women; mean age 44.1+/-13.0 years) who underwent carotid IMT, GA, and HbA1c measurements. RESULTS: The mean GA/A1c ratio was 2.90. Based on these results, we classified the subjects into two groups: group I (GA/A1c ratio <2.90, n=36) and group II (GA/A1c ratio > or =2.90, n=45). Compared with group I, the body mass indexes (BMIs), waist circumferences, and IMTs were lower in group II. GA/A1c ratio was negatively correlated with BMI, urine albumin to creatinine ratio (P<0.001 for both), and both the mean and maximal IMT (P=0.001, both). However, after adjusting the confounding factors, we observed that IMT was no longer associated with GA/A1c ratio. CONCLUSION: In contrast to T2DM, IMT was not significantly related to GA/A1c ratio in the subjects with T1DM. This suggests that the correlations between GA/A1c ratio and the parameters known to be associated with atherosclerosis in T2DM could be manifested differently in T1DM. Further studies are needed to investigate these relationships in T1DM.
