Serum adiponectin concentration according to visceral fat amount and its relationship of metabolic risk factors in premenopausal obese women.
- Author:
Sung Jae KIM
1
;
Keun Gyu PARK
;
Hee Kyoung KIM
;
Mi Kyung KIM
;
Sang Won LEE
;
Jae Seok HWANG
;
Seong Wook HAN
;
Seung Ho HUR
;
In Kyu LEE
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. inkyulee@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Obesity;
Metabolic syndrome;
Visceral fat;
Subcutaneous fat
- MeSH:
Adiponectin*;
Blood Pressure;
Body Fat Distribution;
Body Mass Index;
Fasting;
Female;
Glucose;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Intra-Abdominal Fat*;
Obesity;
Plasma;
Risk Factors*;
Subcutaneous Fat;
Triglycerides;
Waist-Hip Ratio
- From:Korean Journal of Medicine
2004;66(3):259-266
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Adiponectin is adipose specific protein, which we considered to have metabolic and endocrine function in metabolic syndrome including obesity and insulin resistance. We measured serum adiponectin concentrations and compared them with body fat distribution and metabolic risk factors. METHODS: 112 premenopausal obese women were participated in this study. We measured plasma adiponectin concentration and metabolic risk factors such as fasting glucose and insulin, triglyceride, systolic blood pressure (SBP) and diastolic blood pressure (DBP). Subcutaneous adipose tissue area (SAT) and visceral adipose tissue area (VAT) were determined by computed tomography. Body mass index (BMI), waist to hip ratio (WHR) and homeostasis model assessment (HOMA-IR) were calculated. RESULTS: Serum adiponectin concentration was inversely correlated with fasting insulin level, HOMA-IR, triglyceride, SBP, DBP, WHR, BMI and VAT, whereas HDL-cholesterol was positively correlated (all p values<0.05). VAT, SBP, and HDL-cholesterol level were independent variables of serum adiponectin concentrations. CONCLUSION: The present study demonstrates that decreased plasma level of adiponectin is significantly associated with metabolic risk factors including body fat distribution; serum adiponectin level is determined by VAT, whereas SAT has no relation with serum adiponectin level.
