A Case of Steroid induced Myopathy in Patient with Iatrogenic Cushing Syndrome.
- Author:
Jun Goo KANG
1
;
You Hern AHN
;
Joon Sung PARK
;
Chang Beom LEE
;
Yong Soo PARK
;
Dong Sun KIM
;
Woong Hwan CHOI
;
Tae Wha KIM
;
Joon Soo HAHM
;
Yong Wook PARK
;
Eun Kyung HONG
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Kuri, Korea.
- Publication Type:Case Report
- Keywords:
Steroid myopathy;
Type II fiber
- MeSH:
Adenosine Triphosphatases;
Adipocytes;
Atrophy;
Basophils;
Biopsy;
Buffaloes;
Christianity;
Cushing Syndrome*;
Electromyography;
Exanthema;
Female;
Humans;
Hydrogen-Ion Concentration;
Inflammation;
Lower Extremity;
Middle Aged;
Muscular Diseases*;
Needles;
Pharmacy;
Pruritus;
Steroids;
Volition
- From:Journal of Korean Society of Endocrinology
2002;17(2):275-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Many endocrinologic diseases can induce muscular diseases. Myopathy caused by exogenous steroid is a common problem in patients prescribed steroids as therapy. We report a case of iatrogenic steroid myopathy in a 55-year-old female who had taken steroids under her own volition at a local pharmacy for more than 3 months due to skin rash and itching. She complained of severe proximal muscle wasting and weakness in the lower extremities and also exhibited other stigmata of Cushing's syndrome such as moon face, buffalo hump or easy bruising. Needle electromyography showed the typical pattern of myopathy. Muscle biopsy revealed intermixed numerous, markedly atrophic and angulated basophilic fibers and a few fat cells without inflammation. In addition there was marked and selective atrophy of type II fiber on ATPase staining in pH 9.4 buffer. After discontinuation of steroid treatment, she has experienced slow improvement through physical therapy, including isotonic exercise.
