An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ.
10.11637/kjpa.2011.24.4.217
- Author:
Hyuk Jae KWON
1
;
Gi Hee PARK
;
Eun Jung KIM
;
Min Jung LEE
;
Han Sung JUNG
;
Sung Won CHO
Author Information
1. Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei Universit
- Publication Type:Original Article
- Keywords:
Tooth;
Transplantation;
Tooth germ;
Bone marrow
- MeSH:
Adult;
Animals;
Bone Marrow;
Humans;
Kidney;
Mesenchymal Stromal Cells;
Mice;
Periodontal Ligament;
Recombination, Genetic;
Rejection (Psychology);
Tooth;
Tooth Germ;
Transplants
- From:Korean Journal of Physical Anthropology
2011;24(4):217-224
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tooth transplantation using autogenic adult teeth or embryonic tooth germs is the one of best treatments for replacement of missing teeth, but there are limitations in the accessibility. Isogenic or xenogenic tooth transplantation has been failed because of the immune rejection response occurring in the periodontal ligament of transplanted tooth. In this study, by utilizing the recombination between mouse embryonic tooth germ and mouse adult bone marrow stromal cells, we tried to replace the periodontal tissues such as periodontal ligament and alveolar bone with adult bone marrow stromal cells. At four weeks after the transplantation of the recombinant into a kidney, adult bone marrow-derived cells cells were observed in the periodontal ligament and alveolar bone. This result indicates that adult bone marrow stromal cells can participate in the formation of periodontal tissues. If these tooth and periodontal tissues are transplanted into host who donates adult bone marrow stromal cells, adult bone marrow-derived cells will be regarded as host cells, and immune rejection response will not occur in these cells. Therefore, it is suggested that recombination between adult bone marrow stromal cells and embryonic tooth germ is a good candidate method using xenogenic tooth germ for replacement of missing teeth in human by replacing cells in periodontal tissues with human adult bone marrow stromal cells.
