Analysis of Endoscopic Electronic Image of Intramucosal Gastric Carcinoma Using a Software Program for Calculating Hemoglobin Index.
10.3346/jkms.2006.21.6.1041
- Author:
Gwang Ha KIM
1
;
Kwang Baek KIM
;
Eun Kyung LIM
;
Seong Ho CHOI
;
Tae Oh KIM
;
Jeong HEO
;
Dae Hwan KANG
;
Geun Am SONG
;
Mong CHO
;
Do Youn PARK
Author Information
1. Department of Internal Medicine, Pusan National University College of Medicine, 1-10 Ami-dong, Seo-gu, Busan, Korea. gasong@pusan.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Stomach Neoplasms;
Hemoglobin Index;
Software;
Software Validation;
Endoscopy;
Image, Endoscopy
- MeSH:
Tumor Markers, Biological/*analysis;
Stomach Neoplasms/classification/*diagnosis;
*Software;
Sensitivity and Specificity;
Reproducibility of Results;
Neoplasm Proteins/analysis;
Male;
Image Interpretation, Computer-Assisted/*methods;
Humans;
Hemoglobins/*analysis;
Gastroscopy/*methods;
Gastric Mucosa/metabolism/*pathology;
Female;
Colorimetry/methods
- From:Journal of Korean Medical Science
2006;21(6):1041-1047
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hemoglobin is the predominent pigment in the gastrointestinal mucosa, and the development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, by using a hemoglobin index (IHb). The aims of this study were to make a software program to calculate the IHb and then to investigate whether the mucosal IHb determined from the electronic endoscopic data is a useful marker for evaluating the color of intramucosal gastric carcinoma with regard to its value for discriminating between the histologic types. We made a software program for calculating the IHb in the endoscopic images. By using this program, the mean values of the IHb for the carcinoma (IHb-C) and those of the IHb for the surrounding non-cancerous mucosa (IHb-N) were calculated in 75 intestinal-type and 34 diffuse-type intramucosal gastric carcinomas. We then analyzed the ratio of the IHb-C to the IHb-N (C/N ratio). The C/N ratio in the intestinal-type carcinoma group was higher than that in the diffuse-type carcinoma group (p<0.001). In the diffuse-type carcinoma group, the C/N ratio in the body was lower than that in the antrum (p=0.022). The accuracy rate, sensitivity, specificity, and the positive and negative predictive values for the differential diagnosis of the diffuse-type carcinoma from the intestinal-type carcinoma were 94.5%, 94.1%, 94.7%, 88.9% and 97.3%, respectively. IHb is useful for making quantitative measurement of the endoscopic color in the intramucosal gastric carcinoma, and the C/N ratio by using the IHb would be helpful for distinguishing the diffuse-type carcinoma from the intestinal-type carcinoma.
