The relationship among (CA) repeat polymorphism of interleukin(IL)-6 gene, serum IL-6 levels and bone mineral density.
- Author:
Jung Gu KIM
1
;
Seok Hyun KIM
;
Young Min CHOI
;
Shin Yong MOON
;
Jin Yong LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 110-744, Korea.
- Publication Type:Original Article
- Keywords:
Postmenopausal women;
IL-6;
gene polymorphism;
BMD
- MeSH:
Absorptiometry, Photon;
Alleles;
Body Mass Index;
Bone Density*;
Enzyme-Linked Immunosorbent Assay;
Female;
Femur;
Genotype;
Humans;
Interleukin-6*;
Menopause;
Sequence Analysis, DNA;
Spine
- From:Korean Journal of Obstetrics and Gynecology
2001;44(3):587-593
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the relationship between cytosine-adenosine(CA) polymorphism in interleukin-6 (IL-6) gene, serum IL-6 levels and bone mineral density (BMD). METHODS: IL-6 CA polymorphism was analyzed by polyacrylamide-urea gel electrophoretic patterns in 300 postmenopausal Korean women. and direct DNA sequencing. Serum IL-6 was measured by enzyme linked immunosorbent assay, and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry. RESULTS: Nine alleles were observed with product sizes ranging between 120-136 bp and 125 allele was the most common. There were no significant differences in serum IL-6 levels and BMD at the lumbar spine and proximal femur between the women who possessed at least one allele of each genotype and those who did not posses that allele. Serum IL-6 levels did not correlated with age, menopause duration, body mass index and BMD at the lumbar spine and proximal femur. IL-6 CA polymorphic pattern and serum IL-6 levels in osteoporotic women were not different from those in normal BMD or osteopenic women. CONCLUSIONS: IL-6 CA polymorphism has no relationship with serum IL-6 levels and BMD in postmenopausal Korean women.
