The Role of PKMzeta in Drug Reward Memory.
- Author:
Min Ji SONG
1
;
Jeong Hoon KIM
Author Information
1. Department of Physiology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea. jkim1@yuhs.ac
- Publication Type:Review
- Keywords:
PKMzeta;
Addiction;
Reward memory;
Nucleus accumbens;
CPP;
CPA
- MeSH:
Brain;
Brain Diseases;
Cues;
Incidence;
Long-Term Potentiation;
Memory;
Memory, Long-Term;
Nucleus Accumbens;
Piperazines;
Plastics;
Protein Kinase C;
Recurrence;
Reward;
Street Drugs;
Substance-Related Disorders
- From:Korean Journal of Psychopharmacology
2012;23(3):83-87
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug addiction is a chronic brain disease with a high incidence of relapse. Environmental cues that previously and repeatedly associated with drugs of abuse easily evoke relapse to addicts even after long period of drug-free state. Such a long lasting property of conditioning is considered a form of long-term memory and has a strong correlation with synaptic plasticity like long-term potentiation (LTP). Protein kinase M zeta (PKMzeta) has been known to play an important role in the maintenance of long-term memory as well as LTP in various brain areas. Likewise, in a few brain areas examined out of the rewarding circuit, PKMzeta seems to play a similarly important role in the maintenance of conditioned memory. These results suggest that PKMzeta may become a new target to manipulate to reverse pre-formed drug-related memory and accompanied behaviors.
