Prediction of Infarction in Acute Cerebral Ischemic Stroke by Using Perfusion MR Imaging and 99mTc-HMPAO SPECT .
- Author:
Ho Cheol CHOE
1
;
Sun Joo LEE
;
Jae Hyoung KIM
Author Information
1. Department of Radiology, Gyeongsang National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Brain, blood flow;
Brain, ischemia;
MR, perfusion imaging
- MeSH:
Humans;
Infarction*;
Infarction, Middle Cerebral Artery;
Magnetic Resonance Imaging*;
Perfusion*;
Sensitivity and Specificity;
Stroke*;
Technetium Tc 99m Exametazime*;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2002;6(1):55-63
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the predictive values of relative CBV measured with perfusion MR imaging, and relative CBF measured with SPECT for tissue outcome in acute ischemic stroke. MATERIALS AND METHODS: Thirteen patients, who had acute unilateral middle cerebral artery occlusion, underwent perfusion MR imaging, and 99mTc-HMPAO SPECT within 6 hours after the onset of symptoms. Lesion-to-contralateral ratios of perfusion parameters were measured, and best cut-off values of both parameter ratios with their accuracy to discriminate between regions with and without evolving infarction were calculated. RESULTS: Mean relative CBV ratios in regions with evolving infarction and without evolving infarction were 0.58+/-0.27 and 0.99+/-0.17 (p < 0.001), and mean relative CBF ratios in those regions were 0.41+/-0.22 and 0.71+/-0.14 (p < 0.001). The best cutoff values to discriminate between regions with and without evolving infarction were estimated to be 0.80 for relative CBV ratio and 0.56 for relative CBF ratio. The sensitivity, specificity and efficiency of each cutoff value were 80.6, 87.5, 82.7% for relative CBV ratio, and 72.2, 75.0, 73.0% for relative CBF ratio (p > 0.05 between two parameters). CONCLUSION: Measurement of relative CBV and relative CBF may be useful in predicting tissue outcome in acute ischemic stroke.
