A Case of Pulmonary Fibrosis with Microscopic Polyangiitis.
10.4046/trd.2011.70.3.257
- Author:
Jae Ho JEONG
1
;
Sung Hee KANG
;
Se Jung PARK
;
Dal Yong KIM
;
Woo Sung KIM
;
Dong Soon KIM
;
Jin Woo SONG
Author Information
1. Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. skysong3@hanmail.net
- Publication Type:Case Report
- Keywords:
Pulmonary Fibrosis;
Microscopic Polyangiitis;
Antibodies, Antineutrophil Cytoplasmic
- MeSH:
Aged;
Antibodies, Antineutrophil Cytoplasmic;
Biopsy;
Blood Sedimentation;
C-Reactive Protein;
Carbon Monoxide;
Cough;
Cytoplasm;
Female;
Glomerulosclerosis, Focal Segmental;
Hematuria;
Humans;
Idiopathic Pulmonary Fibrosis;
Kidney;
Livedo Reticularis;
Lung;
Microscopic Polyangiitis;
Physical Examination;
Pulmonary Fibrosis;
Respiratory Function Tests;
Respiratory Sounds;
Serologic Tests;
Skin;
Steroids;
Thorax
- From:Tuberculosis and Respiratory Diseases
2011;70(3):257-260
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 65-year-old woman was admitted due to poor oral intake and a dry cough over the previous 3 months. The physical examination was remarkable for bibasilar crackles, and plain chest radiography showed reticulation in both lower lung fields. A pulmonary function test demonstrated a restrictive pattern with a reduced diffusing capacity of the lung for carbon monoxide. High resolution computed tomography showed reticulation and honey-combing in both peripheral lung zones, which was consistent with usual interstitial pneumonia pattern. Her skin showed livedo reticularis. The erythrocyte sedimentation rate and C-reactive protein level were elevated, and hematuria was noted on urinary analysis. A serologic test for auto-antibodies showed seropositivity for Myeloperoxidase-Anti-neutrophil cytoplasmic antibody (MPO-ANCA). A kidney biopsy was performed and showed focal segmental glomerulosclerosis. She was diagnosed as having pulmonary fibrosis with microscopic polyangiitis (MPA) and treated with high dose steroids. Here we report a case of pulmonary fibrosis coexistent with microscopic polyangiitis.
