Primary Malignant Rhabdoid Melanoma.
10.5021/ad.2011.23.S2.S155
- Author:
Bo Young CHUNG
1
;
In Su AHN
;
Soo Ick CHO
;
Hye One KIM
;
Kwang Ho KIM
;
Chun Wook PARK
;
Cheol Heon LEE
Author Information
1. Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea. dermlee@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Malignant melanoma;
Rhabdoid
- MeSH:
Actins;
Desmin;
Diagnosis, Differential;
Forearm;
Humans;
Hyalin;
Inclusion Bodies;
Melanoma;
Middle Aged;
Muscle, Smooth;
Neoplasm Metastasis;
Neuroectodermal Tumors, Primitive, Peripheral;
Peripheral Nerves;
Recurrence;
Rhabdoid Tumor;
Rhabdomyosarcoma;
Silver;
Skin;
Synaptophysin;
Transplants;
Vimentin
- From:Annals of Dermatology
2011;23(Suppl 2):S155-S159
- CountryRepublic of Korea
- Language:English
-
Abstract:
Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. Here, we describe a rare case of primary rhabdoid malignant melanoma. A 54-year-old man presented with a black tumor measuring 3x4 cm on the right forearm. Histologic sections showed a tumor mass with rhabdoid features composed entirely of polygonal neoplastic cells with eccentric nuclei, prominent nucleoli, and large hyaline cytoplasmic inclusions. The tumor cells were immunoreactive with HMB-45, S100, Fontana-Masson silver and vimentin, and negative for smooth muscle actin, CD68, CD34, CD99, synaptophysin, desmin, and PAS. The differential diagnosis for this tumor included malignant peripheral nerve sheath tumor, malignant peripheral neuroectodermal tumor and rhabdomyosarcoma. The patient was treated with a wide excision and a local skin graft. The excised tumor was entirely composed of rhabdoid tumor cells. No recurrence or metastasis was evident 4 months after removal. This article is relevant to rare cases of primary malignant melanomas showing rhabdoid tumor cells over the entire excised lesion.
