Outcomes after bleomycin, etoposide and cisplatin combination chemotherapy in patients with ovarian yolk sac tumor.
10.5468/kjog.2010.53.11.1007
- Author:
Ji Young KIM
1
;
Yu Jung SHIN
;
Jei Won MOON
;
Jeong Yeol PARK
;
Dae Yeon KIM
;
Joo Hak LEE
;
Jong Hyeok KIM
;
Yong Man KIM
;
Young Tak KIM
;
Joo Hyun NAM
Author Information
1. Department of Obsterics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. catgut1-0@hanmail.net
- Publication Type:Original Article
- Keywords:
Malignant ovarian germ cell tumor;
Yolk sac tumor;
Bleomycin;
Etoposide;
Cisplatin
- MeSH:
Bleomycin;
Cisplatin;
Drug Therapy, Combination;
Endodermal Sinus Tumor;
Etoposide;
Female;
Follow-Up Studies;
Humans;
Menstruation;
Neoplasms, Germ Cell and Embryonal;
Pregnancy;
Recurrence;
Retrospective Studies;
Survival Rate;
Yolk Sac
- From:Korean Journal of Obstetrics and Gynecology
2010;53(11):1007-1013
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to evaluate the oncologic and reproductive outcomes of patients with ovarian yolk sac tumor after bleomycin, etoposide, cisplatin (BEP) chemotherapy following surgery. METHODS: Of 145 patients with histologically confirmed malignant ovarian germ cell tumor, 43 had yolk sac tumor and received BEP chemotherapy after surgery. A retrospective analysis of these patients was performed. RESULTS: The mean age of 43 patients was 24.8 years (range, 7 to 59 years). Thirty eight patients were nulliparous. Of 179 BEP chemotherapy cycles, grade 1~2 hematologic and non-hematologic adverse events occurred in 46 cycles in 21 patients. Thirty nine patients showed complete remission, 1 patient showed partial remission, and 3 patient had progressive disease during BEP chemotherapy. After median follow-up time of 57 months (range, 3 to 153 months), 5 patients had recurrent disease and three of them died of disease. The 5-year recurrence free survival rate and overall survival rate were 86% and 94%, respectively. After chemotherapy, all but one premenarchal patients had normal menstruation. Of them 5 patients tried to conceive and 3 of them succeeded in pregnancy. CONCLUSION: BEP chemotherapy was very safe and effective in patients with ovarian yolk sac tumor. Survival outcomes are excellent and reproductive outcomes are promising after BEP chemotherapy.
