Urokinase Plasminogen Activator Receptor Gene Expression and Clinico-Pathologic Feature in Gastric Cancer Patients.
10.5230/jkgca.2004.4.4.207
- Author:
Yong Gil KIM
1
;
Kyung Hee LEE
;
Min Kyung KIM
;
Jae Lyun LEE
;
Myung Sue HYUN
;
Sang Hun KIM
;
Hee Sun KIM
Author Information
1. Department of Hemato-Oncology, College of Medicine, Yeungnam University, Daegu, Korea. exodus94@hanmail.net
- Publication Type:Original Article
- Keywords:
Tumor invasion;
Metastasis;
uPAR;
Gastric cancer
- MeSH:
Blotting, Northern;
Breast;
Colon;
Gene Expression*;
Humans;
Interleukin-8;
Mucous Membrane;
Neoplasm Metastasis;
Peptide Hydrolases;
Plasminogen Activators*;
Plasminogen*;
Prognosis;
RNA, Messenger;
Serine Proteases;
Stomach Neoplasms*;
Survival Rate;
Urokinase-Type Plasminogen Activator*
- From:Journal of the Korean Gastric Cancer Association
2004;4(4):207-212
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PUPOSE: Invasion and metastasis in solid tumors require the action of tumor-associated proteases. The serine protease urokinase-type plasminogen (uPA) and receptor (uPAR) appear to have a major function in these processes. Expression of the uPAR is elevated in breast and colon carcinomas, and this is often associated with invasiveness and poor prognosis. The purpose of this study was to determine whether the expression of the uPAR gene correlates with clinico-pathological parameters in human gastric carcinomas. MATERIALS AND METHODS: We examined the expression of uPAR mRNA by using northern blot analysis and RT-PCR in 35 gastric carcinomas and the surrounding normal mucosa. Macroscopic and histopathological tumor findings and survival rates were obtained from the patient records and from endoscopic, surgical, and pathological reports. RESULTS: The expression of uPAR and was higher in most neoplasms than in the corresponding normal mucosal tissue. uPAR mRNA expression in tumors correlated well with lymph-node metastasis (P<0.02) and tumor stage (P<0.01). The survival rate of patients with tumors displaying high uPAR expression levels was significantly lower (P<0.04) than that of patients without uPAR expression, but IL-8 showed only the tendency of survival difference. CONCLUSION: These results suggest that uPAR may be an important prognostic factor in human gastric carcinomas.
