Effect of Proton Pump Inhibitor and Clopidogrel Combination on the Outcome of Patients with Ischemic Heart Disease.
- Author:
Won Hee KIM
1
;
Sung Pyo HONG
;
Yong Hun KIM
;
Do Hyung KIM
;
Jun Gu CHUNG
;
Il PARK
;
Jung Min LEE
;
Chang Il KWON
;
Kwang Hyun KO
;
Seong Gyu HWANG
;
Pil Won PARK
;
Kyu Seong RIM
Author Information
1. Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. sphong@cha.ac.kr
- Publication Type:Original Article
- Keywords:
Clopidogrel;
Proton pump inhibitors;
Ischemic heart disease
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
Acute Coronary Syndrome;
Cohort Studies;
Heart;
Helicobacter pylori;
Humans;
Myocardial Ischemia;
Platelet Aggregation;
Proton Pump Inhibitors;
Proton Pumps;
Protons;
Retrospective Studies;
Ticlopidine
- From:Korean Journal of Medicine
2011;80(4):434-442
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: It has recently been suggested that proton pump inhibitors (PPIs) might reduce the inhibitory effect of clopidogrel on platelet aggregation. Co-administration of a PPI and clopidogrel in patients with ischemic heart disease may thus alter clinical outcome. We investigated the effect of concomitant use of a PPI with clopidogrel in Korean patients with ischemic heart disease. METHODS: This is a retrospective cohort study of 99 patients with acute coronary syndrome taking clopidogrel and PPIs after discharge from CHA Bundang Medical Center between January 1, 2003, and December 31, 2007. The control group consisted of 99 patients who were matched for age and sex but were not taking PPIs. RESULTS: Patients who received clopidogrel plus PPI had a greater than two times higher risk of re-admission or death (adjusted hazard ratio 2.51; 95% confidence interval [CI] 1.43~4.40; p = 0.001) than those who received clopidogrel alone. Lansoprazole use was associated with an increased risk of re-admission or death (adjusted hazard ratio 2.66; 95% CI 1.45~4.89; p = 0.002). Combined period of administration or Helicobacter pylori infection did not affect the risk of re-admission or death. CONCLUSIONS: Particular attention should be paid when patients with ischemic heart disease are prescribed a combination of clopidogrel and a PPI, since this combination was associated with an elevated risk of re-admission or death.
