Optical Molecular Imaging for Diagnosing Intestinal Diseases.
- Author:
Sang Yeob KIM
1
;
Seung Jae MYUNG
Author Information
1. Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjmyung@amc.seoul.kr
- Publication Type:Review
- Keywords:
Molecular imaging;
Endoscopy;
Fluorescence probe;
Intestinal diseases
- MeSH:
Endoscopy;
Endoscopy, Gastrointestinal;
Fluorescence;
Humans;
Inflammation;
Inflammatory Bowel Diseases;
Intestinal Diseases*;
Molecular Imaging*;
Molecular Probes;
Molecular Targeted Therapy;
Optical Imaging;
Prognosis;
Radiotherapy
- From:Clinical Endoscopy
2013;46(6):620-626
- CountryRepublic of Korea
- Language:English
-
Abstract:
Real-time visualization of the molecular signature of cells can be achieved with advanced targeted imaging techniques using molecular probes and fluorescence endoscopy. This molecular optical imaging in gastrointestinal endoscopy is promising for improving the detection of neoplastic lesions, their characterization for patient stratification, and the assessment of their response to molecular targeted therapy and radiotherapy. In inflammatory bowel disease, this method can be used to detect dysplasia in the presence of background inflammation and to visualize inflammatory molecular targets for assessing disease severity and prognosis. Several preclinical and clinical trials have applied this method in endoscopy; however, this field has just started to evolve. Hence, many problems have yet to be solved to enable the clinical application of this novel method.
