Small lymphocytic lymphoma that developed in a patient with long-standing cold agglutinin disease.
- Author:
Jin Young KIM
1
;
Woo Young PARK
;
Sang Min LEE
;
Ju Youn KIM
;
Hyung Ki LEE
;
Yun Jung KIM
;
Ki Young KWON
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea. kky7412@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Anemia;
Hemolytic;
Autoimmune;
Lymphoma;
Non-Hodgkin's
- MeSH:
Aged;
Anemia;
Anemia, Hemolytic, Autoimmune;
Antibodies;
Autoantibodies;
Biopsy;
Chlorambucil;
Cold Temperature;
Follow-Up Studies;
Herpesvirus 4, Human;
Humans;
Leukemia, Lymphocytic, Chronic, B-Cell;
Lymphocytes;
Lymphoma;
Mycoplasma;
Neck;
Prednisolone;
Thorax
- From:Korean Journal of Medicine
2009;77(3):362-366
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia (AIHA) induced by cold antibodies. CAD constitutes 16~32% of AIHA cases and the causative cold autoantibodies are commonly specific against blood group I or i antigens. CAD is closely related to lymphoid neoplasia and infections such as Mycoplasma and Epstein-Barr virus (EBV). Primary CAD has a tendency to develop into malignant lymphoma over its course. We experienced a case of small lymphocytic lymphoma during the treatment of primary CAD over 11 years. The patient was a 67-year-old man who complained of a neck mass. Node biopsy revealed diffuse neoplastic proliferation of small monotonous lymphoid cells with polygonal or oval nuclei;these cells were CD20- and CD5-positive. Follow-up chest and neck computed tomography after treatment with chlorambucil and prednisolone showed partial resolution and stable disease status for over 2 years. We report a case of small lymphocytic lymphoma that developed in a patient with long-standing cold agglutinin disease for 11 years and review the literature.
