Risk Factors for Post-Lumbar Puncture Headache in a Study of Alzheimer's Disease Biomarkers.
10.12779/dnd.2015.14.1.12
- Author:
So Young PARK
1
;
Min Jeong WANG
;
Jae Won JANG
;
Young Ho PARK
;
Joon Woo LEE
;
SangYun KIM
Author Information
1. Clinical Neuroscience Center, Seoul National University Bundang Hospital, Department of Neurology, Seoul National University College of Medicine, Seongnam, Korea. neuroksy@snu.ac.kr
- Publication Type:Original Article
- Keywords:
post-lumbar puncture headache;
Alzheimer's disease;
risk factor
- MeSH:
Alzheimer Disease*;
Biomarkers*;
Cerebrospinal Fluid;
Diagnosis;
Follow-Up Studies;
Interviews as Topic;
Logistic Models;
Memory;
Needles;
Post-Dural Puncture Headache*;
Retrospective Studies;
Risk Factors*;
Spinal Puncture
- From:Dementia and Neurocognitive Disorders
2015;14(1):12-16
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: In memory clinics, the lumbar puncture (LP) is increasingly being used to evaluate cerebrospinal fluid for biomarkers of Alzheimer's disease (AD). Post-lumbar puncture headache (PLPH) is the most frequent complication of LP, and can prove to be a barrier for the performance of LP. METHODS: We retrospectively collected data from 59 subjects (patients with AD and cognitively healthy controls) who were enrolled in a study aimed to identify AD biomarkers via LP. In order to determine whether subjects experienced PLPH, we assessed recorded follow-up telephone interviews. To analyze the association between the occurrence of PLPH and several demographic- and procedure-related factors, a multiple logistic regression analysis with backward stepwise method was performed. RESULTS: The overall frequency of PLPH was 49.15%. PLPH was more frequent in younger subjects and clinical diagnosis was associated with PLPH. The use of cutting-edge needles was also suggested as a statistically significant factor in the development of PLPH, and was determined to be the only factor that could be modified in order to lower the frequency of PLPH. CONCLUSIONS: Age, clinical diagnosis, and needle type were all determined to be predictive factors of PLPH.
