Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia.
10.5213/inj.2014.18.4.179
- Author:
Su Kang KIM
1
;
Joo Ho CHUNG
;
Byung Cheol LEE
;
Sang Won LEE
;
Kang Hyo LEE
;
Young Ock KIM
Author Information
1. Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Prostatic Hyperplasia;
Receptors, Adrenergic, alpha-1;
Panax;
Testosterone
- MeSH:
Animals;
B-Lymphocytes;
Humans;
Male;
Models, Animal;
Panax*;
Prostate;
Prostatic Hyperplasia*;
Rats;
Receptor, Epidermal Growth Factor;
Receptors, Adrenergic, alpha-1;
RNA, Messenger;
Testosterone
- From:International Neurourology Journal
2014;18(4):179-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Benign prostatic hyperplasia (BPH) is the most common prostate problem in older men. The present study aimed to investigate the inhibitory effect of Panax ginseng C.A. Meyer (P. ginseng) on a rat model of testosterone-induced BPH. METHODS: The rats were divided into 3 groups (each group, n=10): control, testosterone-induced BPH (20 mg/kg, subcutaneous injection), and P. ginseng (200 mg/kg, orally) groups. After 4 weeks, all animals were sacrificed to examine the blood biochemical profiles, prostate volume, weight, histopathological changes, alpha-1D adrenergic receptor (Adra1d) mRNA expression, and epidermal growth factor receptor (EGFR) and B-cell CLL/lymphoma 2 (BCL2) protein expression. RESULTS: The group treated with P. ginseng showed significantly lesser prostate size and weight than the testosterone-induced BPH group. In addition, P. ginseng decreased the mRNA expression of Adra1d as well as the expression of EGFR and BCL2 in prostate tissue. CONCLUSIONS: These results suggest that P. ginseng may inhibit the alpha-1-adrenergic receptor to suppress the development of BPH.
